The various contradictory genre versions of your setting

Cross over with another version of the same setting and shift genre as well as details.

For the example I thought of first, go from the Star Trek TV universe to the Abrams timeline and go quick-cut and lens-flare. Or collide with the strange Star Fleet Battles variant where there are more enemy alien empires and special teams in jackets go on ground missions and see what the PCs make of this. Why did the timeline change to shift the genre to Military SF? Did Kirk die again, it’s usually his fault...

Also, this. This can be the party.

The legendary Vampire: The Requiem chronicle Never Let Go nearly had a Christmas special featuring a very very Vampire: The Masquerade version of the stars. I presume that it would not have been canon...